The Implementation, User Testing and Validation of the Web-based Application for the Population Pharmacokinetic Service: Hemophilia (WAPPS-HEMO) Phase 2

The WAPPS-Hemo project is a centralized, dedicated, web-accessible, actively moderated database that allows participating hemophilia centres to securely input factor VIII/IX plasma levels from sparse samples of their patients, returning individual pharmacokinetic estimates (PK). These estimates are generated by a proprietary automated population PK engine and manually validated.

The specific aims of the service are to:

• Empower hemophilia treatment by facilitating individual PK assessment.
• Allow for the robust estimation of individual PK parameters from a reduced number of plasma samples.
• Enhance knowledge about the value and application of population PK methodology to hemophilia care.

IRB: 1701017866